Biliary atresia (BA)
is a disastrous liver disease of the newborn with unpredictable outcome. Occurring in about 1 in 14.000 live births, first clinical symptoms of this rare disease are difficult to distinguish from the frequent and mostly benign neonatal jaundice. Therefore, diagnosis and surgical therapy are often decided too late, worsening the chance for a better outcome. However, despite successful surgery, fibrosis of the liver is an ongoing process in the majority and patients with BA are the most frequent indication for liver transplantation (LTx) in childhood.